According to reports, the Bigg Boss contestant is likely to feature in one of Salman's upcoming film to be directed by brother Sohail. The film is tentatively titled Radhe. When asked about the news, Karishma said, "I cannot comment on this as of now. I can't say anything." Karishma made her debut as an actress with a Telugu film, Shankar Dada Zindabad (2007) alongside Chiranjeevi. The film is a remake of Rajkumar Hirani's Hindi movie Lage Raho Munna Bhai. She was last seen in the 2010 Telugu film Glamour.
The 30-year-old has hosted TV shows like The Karishma Show, Spa Diaries and Its In.